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products/hemoglobin controls/Variant Hemoglobin Control AD
Variant Hemoglobin Control, AD
Although both hemoglobin D disease and trait hemoglobin AD are extremely rare, the importance of using controls is highlighted by the fact that hemoglobin S and hemoglobin D migrate similarly upon alkaline (pH 8.6) electrophoresis. This is so because both hemoglobin S and D arise from single, similarly charged amino acid substitutions on the beta-globin chain. The substitution is at position six in hemoglobin S and 121 for hemoglobin D. Hemoglobin D doesn’t sickle using the standard laboratory techniques but does have a higher than normal oxygen affinity. Using selective laboratory techniques and controls allows the correct diagnosis of hemoglobin D trait or disease.
- HB-120 6X0.5 ml (DIMDI Reg.-Nr.: DE/CA22/1116-224-IVD)
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