Clinical Applications:
Atrophic Gastritis: It was found that a serum pepsinogen I level failed to less than 20 ng/ml was highly specific for severe atrophic gastritis. It is observed that serum pepsinogen I levels fell with increasing severity of mucosal damage in atrophic gastritis. The diagnostic sensitivity and specificity of serum pepsinogen I level for advanced atrophic corpus gastritis are about 92% and 90% respectively. On the other hand, the decrease in serum pepsinogen I levels in patients with pernicious anemia and atrophic gastritis was found to be associated with normal or raised pepsinogen II levels. Therefore, a pepsinogen I / pepsinogen II ratio was significantly lower than those with superficial gastritis or normal remnant mucosa.

Stomach Cancer:
Low serum pepsinogen I levels were found in patients with
gastric cancer, with a threefold higher incidence. Other studies have concluded that
abnormally low levels of serum pepsinogen I and the pepsinogen I / pepsinogen II
ratio may identify persons at increased risk for intestinal types of stomach cancer.
Duodenal Ulcer: A low serum pepsinogen I level can exclude a diagnosis of
duodenal ulcer. Although a high pepsinogen I level has less clinical useful for
establishing the diagnosis of a duodenal ulcer, the combination of of
hypergastrinemia and a highly elevated serum pepsinogen I strongly suggests the
possibility of the Zollinger-Ellison syndrome.
Human Pepsinogen I & II ELISA

Assay format:
“sandwich” immunoenzymometric assay

Patient sample: serum
Sample volume required: 0.05 mL
Normal range: 25 - 200 ng/mL
Assay incubations: 1 h / 20 min

References:

• Kikuchi S. et al. Serum pepsinogen as a new marker for gastric carcinoma among young adults. Cancer 1994;73:2695-2702
• Konishi N, et al. Tissue and serum pepsinogen I and II in gastric cancer identified using immunohistochemistry and rapid ELISA. J Clin Pathol 1995;48:364-367
• Yoshuihara M. et al. Correlation of ratio of serum pepsinogen I and II with prevalence of gastric cancer and adenoma in Japanese subjects. Am J Gastroenterol 1998;93:1090-1096
• Miki K, et al. Usefulness of gastric cancer screening using the serum pepsinogen test method. Am J Gastroenterol 2003 98:735-739.

Order Information:
EDI™ Human Pepsinogen I ELISA Kit I 96 tests I Cat. No. KT 810
EDI™ Human Pepsinogen II ELISA Kit I 96 tests I Cat. No. KT 811

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